The Clinton Herald, Clinton, Iowa

AP story section

October 9, 2013

Scientists peek into baby genes

WASHINGTON, D.C. — Little Amelia Sloan is a pioneer: Shortly after her birth, scientists took drops of the healthy baby’s blood to map her genetic code.

Amelia is part of a large research project outside the nation’s capital that is decoding the DNA of hundreds of infants. New parents in a few other cities soon can start signing up for smaller studies to explore if what’s called genome sequencing — fully mapping someone’s genes to look for health risks — should become a part of newborn care.

It’s full of ethical challenges.

Should parents be told only about childhood threats? Or would they also want to learn if their babies carried a key gene for, say, breast cancer after they’re grown? Could knowing about future risks alter how a family treats an otherwise healthy youngster? And how accurate is this technology — could it raise too many false alarms?

This is the newest frontier in the genetic revolution: how early to peek into someone’s DNA, and how to make use of this health forecast without causing needless worry.

“This was something that was looming over the horizon,” said Dr. Alan Guttmacher, a pediatrician and geneticist at the National Institutes of Health. Last month, NIH announced a $25 million, five-year pilot project in four cities — Boston, San Francisco, Chapel Hill, N.C., and Kansas City, Mo. — to start answering some of the questions before the technology is widely offered for babies.

Today, the 4 million U.S. babies born annually have a heel pricked in the hospital, providing a spot of blood to be tested for signs of at least 30 rare diseases. This newborn screening catches several thousand affected babies each year in time for early treatment to prevent death, brain damage or other disabilities. It’s considered one of the nation’s most successful public health programs.

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