The Clinton Herald, Clinton, Iowa

Food & Health

September 11, 2013

Drug works in early breast cancer

(Continued)

The panel will review a 417-woman study comparing Perjeta in different combinations against older breast cancer treatments. When Perjeta was combined with Herceptin, another Genentech drug, and standard chemotherapy, 39 percent of women saw their cancer reach undetectable levels.

Only 21 percent of women experienced the same results from taking Herceptin and chemotherapy alone. After drug treatment all the women received standard breast surgery to remove any cancerous tumors. Genentech says this surgery allowed researchers to confirm the presence or absence of cancer.

Last year the FDA released guidelines for studying breast cancer drugs in the pre-surgical setting, with the aim of accelerating approval of promising therapies. Perjeta is the first drug to undergo FDA review since those recommendations were released. If approved, it could encourage more drugmakers to study cancer drugs for early-stage use.

“Despite advances in systemic therapy of breast cancer, there remains a need to expedite drug development and approval of highly effective therapies for patients with high-risk early-stage breast cancer,” the FDA states in its review.

Like Herceptin, Perjeta only works in a subset of about 20 percent of breast cancer patients who have tumors that overproduce a protein known as HER-2, which makes cancer cells rapidly divide and grow.

Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute. About 6,000 to 8,000 deaths per year are attributed to the HER-2 form of the disease.

FDA scientists stress in their review that Genentech’s results are preliminary and will have to be confirmed in future trials. The company only measured the patients’ immediate response to the drug, and did not submit follow-up data showing whether the cancer returned or whether women ultimately lived longer.

But agency scientists said the company’s approach “is reasonably likely to predict clinical benefit,” and noted that Genentech is already enrolling patients in a late-stage trial that could confirm the results.

Text Only
Food & Health
  • Why a see-through mouse is a big deal for scientists

    A group of Caltech researchers announced in Cell Thursday their success in making an entire organism transparent. Unfortunately, this isn't any kind of "Invisible Man" scenario: The organism in question is a mouse, and the mouse in question is quite dead.

    August 1, 2014

  • Sunburn isn't the only sign of summer that can leave you itchy and blistered

    You've got a rash. You quickly rule out the usual suspects: You haven't been gardening or hiking or even picnicking, so it's probably not a plant irritant such as poison ivy or wild parsnip; likewise, it's probably not chiggers or ticks carrying Lyme disease; and you haven't been swimming in a pond, which can harbor the parasite that causes swimmer's itch.

    July 31, 2014

  • Fist bump photo Study: Fist bumps less germy than handshakes

    When it comes to preventing the spread of germs, maybe the president is on to something with his fondness for fist bumps.

    July 30, 2014 1 Photo

  • Watermelon Think beyond the slice with refreshing watermelon

    Watermelon is one of those foods you really don’t need to overthink.
    Slice it. Eat it. Spit out the occasional seed. Done.

    July 27, 2014 1 Photo

  • Health insurers owe Iowans nearly $1.8M in refunds

    The federal government says insurers owe Iowans nearly $1.8 million in refunds because of a provision in the Affordable Care Act.

    July 24, 2014

  • Agents get subsidized 'Obamacare' using fake IDs WASHINGTON (AP) — Undercover investigators using fake identities were able to secure taxpayer-subsidized health insurance under President Barack Obama’s health care law, congressional investigators said Wednesday.The weak link seemed to be call cente

    July 24, 2014

  • Almost half of America's obese youth don't know they're obese

    The good news is that after decades of furious growth, obesity rates finally seem to be leveling off in the U.S.. The bad news is that America's youth still appear to be dangerously unaware of the problem.

    July 23, 2014

  • Illinois patients to docs: 'What about marijuana?'

    Illinois doctors, nursing homes, hospitals and hospice organizations are ramping up for their role as gatekeepers in the state's new medical marijuana program.

    July 23, 2014

  • Amanda Stecker Herbs make a better way to flavor meals Summer is a season full of fresh herbs. This is the best time of year to take advantage of the fresh herbs in the grocery store. Herbs add a boost of flavor without added sodium and are rich in antioxidants. Herbs are easy to incorporate into everyda

    July 23, 2014 1 Photo

  • Genome Genetic mapping triggers new hope on schizophrenia WASHINGTON, D.C. — Scientists have linked more than 100 spots in our DNA to the risk of developing schizophrenia, casting light on the mystery of what makes the disease tick.Such work could eventually point to new treatments, although they are many y

    July 23, 2014 1 Photo

Parade
Magazine

Click HERE to read all your Parade favorites including Hollywood Wire, Celebrity interviews and photo galleries, Food recipes and cooking tips, Games and lots more.