BOSTON — Andrew Benintendi hit a solo homer off Jake Arrieta during a five-run first inning and the Boston Red Sox held on to beat the Chicago Cubs 5-4 on Friday night in an interleague game.

Every Boston starter had at least one hit, and Hanley Ramirez, Mitch Moreland, Jackie Bradley Jr. and Christian Vazquez also drove in a run each.

Left-hander Drew Pomeranz (2-1) got the win with six innings of two-run ball, surrendering solo homers to Kris Bryant and Albert Almora Jr. in the early innings before settling in. He allowed six hits and two walks while striking out seven.

Boston has won its past nine interleague games at Fenway Park.

Craig Kimbrel got his eighth save.

Arrieta (3-1) logged his shortest start since Aug. 28, 2014, lasting only 4 1/3 innings and giving up 10 hits and three walks with five strikeouts.

Arrieta also had a tough beginning against Cincinnati in his last start, and it is the first time in his career that he has allowed four first-inning earned runs in consecutive outings. Arrieta took a no-hitter into the eighth inning in his last start in Boston on June 30, 2014.

Ben Zobrist also drove in a run for Chicago, which is playing its third regular-season series at Fenway and first since 2014.

Bryant blasted his third homer of the season over the Green Monster in left field to put the Cubs ahead 1-0 in the first.

Boston teed off against Arrieta in the bottom half, forcing the 2015 NL Cy Young Award winner to throw 42 pitches. Benintendi’s second homer of the season sailed into the Boston bullpen in right-center with one out to tie it, Mookie Betts doubled and Ramirez brought him in with his soft single to right. Moreland plated Ramirez on his ensuing double to right before Bradley and Vazquez added RBI singles.

White Sox win again

DETROIT — Geovany Soto broke open a tie game with a two-run single in the eighth inning, helping the Chicago White Sox beat the Detroit Tigers 7-3 at Comerica Park on Friday night.

Anthony Swarzak (2-0) pitched two scoreless innings for the White Sox, who won their fifth straight.

Tigers reliever Alex Wilson (0-1) allowed two hits and two unearned runs in the eighth. Detroit third baseman Nick Castellanos committed two errors in the inning, and three in the game, leading to Soto’s go-ahead hit.

Former Tigers pitcher Mike Pelfrey started for Chicago and went 4 2/3 innings, allowing three earned runs on six hits. He walked four and struck out two.

Detroit got to Pelfrey early, jumping to a 2-0 first-inning lead on Justin Upton’s bases loaded, two-run single. The Tigers loaded the bases again that inning, but Jim Adduci grounded into a double play to end the threat.

The White Sox answered in the top of the second, getting back-to-back home runs from Todd Frazier and Avisail Garcia off Detroit starter Matt Boyd to tie the score at 2-2.

Chicago took a 3-2 advantage in the third on Garcia’s RBI single, and the Tigers tied it on Victor Martinez’s RBI single in the fifth.

Melky Cabrera began the top of the eighth with a single, and Frazier reached base on Castellanos’ first error of the inning. Garcia followed with a hard hit ball to third, which Castellanos could not handle, loading the bases.

After Wilson induced a double play, with the runner being forced out at home, Yolmer Sanchez received an intention walk to reload the bases. Soto then delivered the big hit.

Tim Anderson added a two-run homer in the ninth to extend Chicago’s lead to 7-3.

Boyd pitched seven innings, allowing three earned runs on seven hits. He stuck out five and walked two.

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