Ashford cut the lead in half in the bottom of the inning thanks to an Acevedo RBI single, but two more Mustang runs in the seventh extended the lead to three.
The Saints threatened in their final at-bat, loading the bases with one out. But AU couldn’t get a runner home as Mustangs reliever Michael Stellmack retired the final two batters to earn the save.
Sotiropoulos (3-4) allowed two runs on three hits in 3 1/3 innings, walking two and striking out one in defeat.
The Saints will hit the road for their final four games of the season, starting with a doubleheader against Viterbo University on Thursday in LaCrosse, Wis.